You can set your SmartPaths, designate a SmartPath as a SuperSmartPath and set a variety of other settings via the Settings screen.
Please note that SmartPath settings are pointers to the folders that the numbers and the nicknames represent. They are not the folders themselves. Deleting a SmartPath does not affect the actual files. Only the pointer in the profile is deleted, never any actual files.
See also: Creating a New Profile